To investigate the hypoglycemic effect of the submerged culture of the Ceriporia lacerata mycelium (CL) species, in-vitro and in-vivo tests were executed using INS-1 and 3T3-L1 cells, normal and diabetic mice. CL exhibited an inhibitory effect on cell death through dexamethasone in the INS-1 cells, and increased the GLUT4 expression in the 3T3-L1 cells. A hematological monitoring test was executed using diabetic mice divided into four groups : normal control (G1), negative control (G2), positive control (G3), and CL 250 mg/kg (G4) groups, which were fed daily for 6 weeks. The body weight gain, food intake, and water intake of G4 were not significantly different from those of G2. After 5 weeks, the blood glucose levels of G4 were significantly different from those of G2. After 6 weeks, the plasma insulin levels of G4 increased by about 36% compared to those of G2, and the plasma C-peptide levels of G4 were lower by about 18%. than those of G3. The results of the oral glucose tolerance test (OGTT) showed that CL lessened the blood glucose levels of G4 by 15% compared to G2.
It was concluded that CL stimulates the proliferation of beta cells and promotes insulin secretion and may thus have a potential in improving the hypoglycemic effects among the diabetic symptoms. Perhaps if I explain things, micro cultivation of mushroom, Mushrooms are fungi, which are so distinct in nature they are classified as their own kingdom – separate from plants or animals. While commonly placed in the vegetable category for dietary recommendations, mushrooms are, however, not a vegetable based on their cellular organization and composition such as chitin and ergosterol. In fact, as the authors of a recent Nutrition Today article noted, mushrooms’ nutrient and culinary characteristics suggest it may be time to re-evaluate food groupings and health benefits in the context of three separate food kingdoms: plants/ botany; animals/zoology and fungi/mycology. Also •Mushrooms are a good source of B vitamins, including riboflavin, niacin, and pantothenic acid, which help to provide energy by breaking down proteins, fats and carbohydrates2. B vitamins also play an important role in the nervous system. ◦Pantothenic acid helps with the production of hormones and also plays an important role in the nervous system.
◦Riboflavin helps maintain healthy red blood cells.
◦Niacin promotes healthy skin and makes sure the digestive and nervous systems function properly
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