Protecting our body from what is not a part of our body is called immunity, and the mechanism that works for this is called the immune system. The immune system plays a role in blocking, attacking, and destroying external factors, and diseases-causing pathogens such as viruses, parasites, and bacteria, and tumor cells are external factors. The immune system can be largely classified into innate immunity and acquired immunity, and the two immune systems work together to maintain the body’s defense line. Innate immunity is a defense that has been in place since birth, responding to all non-specific external factors that invade our body, and acquired immunity is an immunity acquired through experience, remembering specific targets already experienced and destroying them.It is also called non-specific immunity because it acts without distinguishing the types of external substances that invade the innate immune hideout. It is a protective mechanism that reacts first to all pathogens and is classified into a first defense line and a second defense line. The first defense line is the skin and mucous membrane, and the second defense line includes defense cells, defense proteins, inflammation, and heat. First line of defense: physical barrier, chemical barrier. Physical and chemical barriers protect the body from pathogens on the front line. First, the outer layer of the skin in contact with external factors acts as a physical barrier to defend against invasion of pathogens. The barrier is firmly maintained through intercellular bonding, and Keratin, one of the components that makes up the cell, allows the skin cells that make up the barrier to withstand enzymes and toxins emitted by weak acids, bases, and external factors.Substances secreted by the gland in the skin also function as chemical barriers. The acid components of sweat and sebum secreted by skin glands slow the growth of bacteria. In addition to skin glands, acid components of vaginal secretions, gastric acid secreted from the stomach wall, and enzymes called lysozyme contained in saliva and tears act as chemical barriers to prevent pathogen growth. Mucus is secreted from mucous membranes in tissues such as the nose and throat. Second line of defense: defensive cells, inflammatory reactions, defensive proteins, heat. It is a non-specific defense system that blocks all kinds of pathogens that enter our body through physical and chemical barriers, and the action through defensive cells, defense proteins, inflammatory reactions, and heat is included in the second defense line. Defensive cells eat and destroy invading microorganisms and parasites or kill abnormal cells infected with them, and large phagocytes and natural killer cells function like this. Large phagocyte is a phagocyte that grows after white blood cells in the blood move into the tissue and undergoes phagocytosis to ingest and remove pathogens. Large phagocytes capture pathogens into the cell and secrete lysozyme, a digestive enzyme, and use digestive enzymes to fragment pathogens. After predation, fragments of pathogens are released out of the cell. Natural killer cells roam the body and induce self-destruction of cells infected with viruses or with tumor properties. Perforin and granzyme, which are proteases, are injected into abnormal cells by drilling holes on the surface of abnormal cells to induce self-destruction of the cells, and in addition to this, preventing further damage to normal cells around them.Damage to tissues caused by viral infection causes an inflammatory reaction. Acute inflammation activates the local immune mechanism, and in this process, it is accompanied by four basic signs of inflammation: redness, fever, edema, and pain. The inflammatory reaction begins with the release of various chemicals, of which cytokine emitted by large phagocytes, histamine emitted by obese cells, and prostaglandin are typical.
Cytokines trigger inflammatory reactions and attract white blood cells to tissue-damaged areas, and histamine and prostaglandin expand the fibrillar vein, increasing blood flow in the damaged area and increasing capillary permeability. Local blood flow and increased capillary permeability wash away harmful substances such as toxins emitted by intruders, weakening their effects, and increasing the inflow of defensive proteins and healing factors into tissues. However, at the same time, local congestion caused by increased blood flow causes redness and heat, and increased permeability causes a large amount of moisture to escape from capillaries to interstitial fluid, a liquid that fills cells, resulting in edema and pain.Defense proteins have interferon and complement, and are responsible for slowing viral replication and enhancing other defense mechanisms. Interferon is a glycoprotein that is synthesized within virus-infected cells and secreted into normal cells around it. Interferon combines with normal cells to produce antiviral proteins that allow the cells to inhibit viral reproduction, thereby preventing further transmission. A complement system is composed of more than 20 plasma proteins that usually float in the blood in an inactive state. The complement mainly helps strengthen the innate immune mechanism, but it also plays a role in enhancing the acquired immune mechanism, such as destroying pathogens. When the complement is activated due to infection in the body, the inflammatory reaction is strengthened, and a membrane attack complex (MAC) formed by combining some of the constituent glycoproteins is used to puncture and dissolve the surface of a specific pathogen.
Imu Barrier Corporation’s (CEO: Ryohei Nishikubo) is a company that The form of synthetic duplex RNA is the result of thermal processing of cytidylic acid and inosinic acid. For use purposes, it is used as a vaccine supplement and an immunoactive drug supplement. Usually, other companies are distributed through a sieve and have to maintain minus 20 degrees Celsius when distributing, but they are the only ones in the world that succeeded in powdering that can be distributed at room temperature. The main role and efficacy are used to prevent virus invasion from the outside, kill and reduce the role of virus and bacterial antibodies that have penetrated the body, and in addition, the Imubarrier Corporation powder can even help produce antibodies. The humidifier is my hope to launch in the future, and now that I have completed the internal type, I would like to develop that as the main product.
▲Imu Barrier Corporation
▲ +81-6-4980-9464
▲Ryohei Nishikubo
▲https://immubarrier.co.jp/
▲ Info@immubarrier.co.jp
